Search results for "polymer-drug carrier"

showing 2 items of 2 documents

Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium

2013

Current malaria therapeutics demands strategies able to selectively deliver drugs to Plasmodium-infected red blood cells (pRBCs) in order to limit the appearance of parasite resistance. Here, the poly(amidoamines) AGMA1 and ISA23 have been explored for the delivery of antimalarial drugs to pRBCs. AGMA1 has antimalarial activity per se as shown by its inhibition of the in vitro growth of Plasmodium falciparum, with an IC50 of 13.7 μM. Fluorescence-assisted cell sorting data and confocal fluorescence microscopy and transmission electron microscopy images indicate that both polymers exhibit preferential binding to and internalization into pRBCs versus RBCs, and subcellular targeting to the par…

Drug3003PlasmodiumPolyamineErythrocytesPrimaquinemedia_common.quotation_subjectmalariaPharmaceutical ScienceAntimalarialPrimaquinePharmacologyParasitemiatargeted drug deliveryAntimalarialsMiceChloroquineparasitic diseasesPolyaminesmedicineAnimalsInternalizationDrug Carriermedia_commonDrug CarriersMice Inbred BALB CbiologyAnimalPlasmodium falciparumChloroquinePoly(amidoamine)polyamidoaminebiology.organism_classificationnanomedicineErythrocyteTargeted drug deliveryFemalepolymer-drug carrierPlasmodium yoeliimedicine.drug
researchProduct

NOVEL PAHY-GRAFT COPOLYMERS AS MICELLAR DRUG CARRIER FOR ANTICANCER DRUGS

2009

polymer-drug carrier-micelles
researchProduct